WebNov 21, 2024 · However, Rnf2 −/− RAW264.7 cells showed increased nuclear accumulation of STAT1 after IFN-β stimulation compared with that in wild-type RAW264.7 cells (Fig. … WebOct 22, 2024 · For instance, in mouse macrophages, in addition to H2A ubiquitination and chromatin compaction, RNF2 has been demonstrated to promote STAT1/STAT2 …
Interferons up-regulate STAT1, STAT2, and IRF family …
Web*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways. WebJan 9, 2024 · A STAT1 dimer bound to a GAS DNA sequence (1BG5) was positioned on the first 5′-GGAA-3′ repeat. A homology model of the IRF9 DBD was positioned on the second … free chibi bases
Dysregulation of the IFN-γ-STAT1 signaling pathway in a
WebGene expression (Transcription) SuperPath Pathway network for Gene expression (Transcription) SuperPath WebJan 29, 2024 · Subsequent stimulation of JAK2/STAT1 and TLR4 pathways leads to signal integration , and the STAT1 signaling pathway has been suggested to cross-link innate and adaptive immunity (12, 28, 52). Additionally, STAT1 has been postulated to be important for macrophage development ( 32 , 37 , 61 ), where it is believed to skew the phenotype … WebSTAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated … free chibi