Web21 okt. 2024 · Numb Splicing. The trafficking protein Numb comes in four flavors, each with a short or long version of the phosphotyrosine-binding domain (PTB) and the proline-rich region (PRR). [Courtesy of Lacomme et al., Science Advances, 2024.] To find out, Lacomme expressed each Numb isoform along with human tau in human kidney cells. WebAntibodies that detect NUMB can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry and Immunoprecipitation. These antibodies target NUMB in Human, Mouse, Rat, Non-human primate and Chicken samples. Our NUMB monoclonal, polyclonal and recombinant …
The role of NUMB/NUMB isoforms in cancer stem cells - BMB …
Web12 nov. 1999 · The specificity of the Numb isoform antibodies was determined by testing their ability to specifically recognize ectopically expressed Numb proteins. To this end, … Web29 mrt. 2024 · Numb inhibits migration and promotes proliferation of colon cancer cells via RhoA/ROCK signaling pathway repression. Loss of Numb promotes hepatic … i know he is annoying
Numb regulates Tau levels and prevents neurodegeneration in …
Web29 sep. 2016 · The endocytic adaptor protein Numb has a major role in development as an intrinsic regulator of cell fate determination and inhibitor of the Notch signaling pathway. … WebThe role of NUMB/NUMB isoforms in cancer stem cells Hye Yeon Choi 1,* , Jaekwon Seok 2 , Geun-Ho Kang 2 , Kyung Min Lim 2 & Ssang-Goo Cho 2,* 1 Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA, 2 Department of Stem Cell and Regenerative Biotechnology, Molecular & Cellular … Web2 feb. 2024 · Deregulated alternative splicing of the endocytic adaptor NUMB resulting in high expression of Exon9in (exon 9-containing) isoforms has been reported in several cancer types. However, the role of Numb isoform expression in tumor progression and the underlying mechanisms remain elusive. i know he heard my prayer gaither