WebMar 15, 2004 · In the human immune system PDCs and B cells express TLR9 and thus are sensitive to CpG ODN, whereas monocytes, myeloid DCs, T cells, and NK cells are … WebApr 15, 2003 · In this study, we investigated CpG-dependent IP-10 production. CpG-A ODN were found to be potent inducers of IP-10 secretion, effecting pDC directly, while in monocytes the effect was indirect and mediated by pDC-derived IFN-α. We found no evidence for direct stimulation of highly purified human monocytes by any CpG ODN.
Intra-tumoral injection of CpG oligonucleotides induces the ...
WebJun 4, 2024 · Introduction. Monocytes are innate immune cells that account for ~10% of nucleated blood cells (1, 2).They play a key role in anti-microbial immunity through direct … WebJun 4, 2024 · Introduction. Monocytes are innate immune cells that account for ~10% of nucleated blood cells (1, 2).They play a key role in anti-microbial immunity through direct responses including phagocytosis and cytokine production in addition to regulating other cells of the innate and adaptive immune systems ().Under inflammatory conditions blood … corporate consulting associates inc
Stimulation of bone resorption in vitro by a non-prostanoid …
WebUpon stimulation with a suboptimal concentration of CpG-ODN 2216 (0.1 µM), 1 µM of LEN enhanced pDC-derived IFN-α production (185% of vehicle control culture; p=0.023) . These results indicated that exposure to a clinical concentration of LEN sustained and potentially enhanced, IFN-α production by pDCs in response to weak CpG stimulation. WebFeb 9, 2015 · Cell stimulation. Human monocytes were incubated with CpG-ODN 2006 (5 µg/mL) in the presence or absence of MBL (10 µg/mL). MBL protein was pre-incubated with CpG-ODN 2006 for 30 min at room temperature for complex formation prior to incubation. ... C3 suppresses CpG-ODN 2006 uptake into human monocytes, thus blocking CpG … WebApr 13, 2024 · The human THP-1 monocyte line and human hepatocellular carcinoma cell line HepG2 cells were obtained from the Cell Centre of Peking Union Medical College. HUVECs were maintained in growth medium including 1/3 endothelial cell medium (ECM) (ScienCell) and 2/3 M199 medium (Gibco) supplemented with 10% (v/v) foetal bovine … corporate consultants of america