WebRusso and co-authors compared the energy barriers of AP-1′s and cisplatin’s hydrolysis processes and found that the hydrolysis of AP-1 is more favorable . Depending on the basis set used for DFT calculations, the activation barriers for hydrolysis of cisplatin are in the 25 kcal/mol–30 kcal/mol range [51,57]. The higher cytotoxic ... WebMost sources say that cisplatin is soluble in water and saline at around 1 mg/ml - 2.5 mg/ml depending on the source. I saw in the attached article (under liposome preparation method) that they...
Hydrolysis of cis- and transplatin: structure and reactivity …
WebThe cisplatin hydrolysis products are more toxic than the parent drug itself. Sodium thiosulfate was successfully used to reduce toxic side effects of cisplatin hydrolysis products [7]. Because of the severe side effects, cisplatin is administrated in small doses at low concentrations. For these reasons, WebJan 16, 2024 · The hydrolysis of cisplatin was analyzed under a confined regime. The Cl - /H 2 O exchange process was calculated for free cisplatin in aqueous solution and … dhhl waitlist for maui
Hydrolysis of cisplatin - A first-principles metadynamics …
WebSep 9, 2014 · Cisplatin undergoes hydrolysis within the cell producing a highly reactive charged platinum complex [Pt(NH3)2ClH2O]+. After further hydrolysis, this complex binds to DNA bases through the N7 atom (preferably guanine). This DNA cross-linkage mechanism interferes with cell division and replication. WebCisplatin, cis - [PtCl 2 (NH 3) 2 ], is extensively used for the treatment of testicular and ovarian cancers and increasingly against other types of solid tumors (head/neck, lung, cervical, and bladder) ( 1 , 2 , 3 , 4 ). The cytotoxic effect of cisplatin is thought to be due to attack on DNA bases and induction of apoptosis in cancer cells ( 5 , 6 WebApr 11, 2024 · Cisplatin (CISPt) III: Systemic: Lipid coated [email protected] increased the transdermic drug administration. Lipid coating avoided the toxic accumulation of CISPt in other organs, highly reducing its systemic toxicity: Tu et al. Ovalbumin (OVA) IV: Systemic dhhl property